Permanent Breast Seed Implant (PBSI) is a form of internal radiation therapy that involves radioactive seeds (Palladium-103) being percutaneously implanted in the cavity. This form of radiation is proven to be just as effective as standard external radiation therapy and significantly reduces the duration of radiation therapy: only one follow-up treatment is needed after the first treatment. PBSI is not yet administered in Europe. However, it was introduced as a new treatment in the Erasmus MC hospital in collaboration with Franciscus Gasthuis and Vlietland by our research team in August 2017. The most common side effects of PBSI are skin-related: they have a negative impact on cosmetics and quality of life. This research aims to examine and evaluate the effect of a subcutaneous injection with liquid on skin damage after PBSI. The radiochromic film that can be used to predict the risk on skin damage is investigated and published in Physics in Medicine and Biology. The protocol of this study is published in Trials.
Palladium seeds in a breast shown on a mammogram. Source: BreastMicroseed inc.